Special SWAN lecture by
Jared Rutter

​​Jared Rutter, PhD, is distinguished professor of biochemistry in University of Utah and a member of the Nuclear Control of Cell Growth and Differentiation Program at Huntsman Cancer Institute. He is an HHMI  investigator since 2015.

 

Jared is a visionary leader in the field of molecular metabolism and signaling. His is specially interested how metabolic pathways impact cellular fate decisions, with implications  for cellular decisions to differentiate or proliferate –  crucial relevance for biology and diseases.

 

His original identification of mitochondrial pyruvate carrier provided molecular understanding and tools to intervene Warburg effect, first described in cancers but induced also in metabolic stress responses of postmitotic cells from astrocytes in the nervous system, the muscle or the heart.  Indeed, pyruvate metabolism is crucial for all differentiation/ proliferation events -  e.g. from T and B cells to general maintenance of glucose homeostasis in tissues and diseases. 

 

Please come and be ready to learn of the fascinating world of metabolism.

Jared also serves an opponent of Simon Andersson on 14th of October at 13.00 in Viikki Biocenter 2 , Auditorium 1041.

 

Selected publications:​

The secret life of lactate: A novel cell-cycle regulatory mechanism

Cluntun AA, Rutter J. Cell Metab 2023; 35: 730-732

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Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns

Berg JA, Zhou Y… and  Rutter J. Nat Cell Biol 2023; 25: 616-625

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Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Hicks KG, Cluntun AA, … and  Rutter J. Science 2023; 379: 996-1003

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Metabolites as signalling molecules

Baker SA, Rutter J. Nat Rev Mol Cell Biol 2023; 24: 355-374

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Enhancing mitochondrial pyruvate metabolism ameliorates ischemic reperfusion injury in the heart

Visker JR, Cluntun AA, … and Rutter J. JCI Insight 2024; 9: e180906

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Stressed to death: Mitochondrial stress responses connect respiration and apoptosis in cancer

Winter JM, Yadav T, Rutter J. Mol Cell 2022; 82: 3321-3332

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The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

Cluntun AA, … and Rutter J, Drakos SG. Cell Metab 2021; 33: 629-648.e10

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A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans

Bricker DK, … and  Rutter J. Science 2012; 337: 96-100