Special SWAN Seminar by
Jan Miljkovic

Dr. Jan Miljković is a leading expert in mitochondrial and redox biologist whose work uncovers how sulfur metabolism, H₂S signaling, and redox‑driven protein modifications shape cellular responses under metabolic stress. As a Senior Research Associate at the MRC Mitochondrial Biology Unit, University of Cambridge, he leads projects on mitochondrial sulfur pathways, ischemia/reperfusion injury, aging, and organelle‑specific stress responses. His publication record demonstrates sustained impact on redox‑metabolism crosstalk and stress‑adaptation biology. Dr. Miljković’s contributions include developing advanced metabolomic workflows to quantify H₂S‑based modifications and uncovering how sulfur‑dependent signaling integrates with mitochondrial function in cardiometabolic and neurodegenerative disease contexts.

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Selected publications: 

Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H₂S in biological samples

J.L. Miljkovic, N. Burger, C.S. Yu, A.H. Harkiss, S. Warrington, S.T. Caldwell, S.A. Jones, J.J. Lee, D. Aksentijevic, A.M. James, T. Krieg, R.C. Hartley, M.P. Murphy
Nature Communications (2025)

MitoPerSulf: Mitochondrial‑Targeted Protection Against Cardiac Ischemia‑Reperfusion via Rapid Persulfide and H₂S Release

J. Miljkovic, N. Burger, J.M. Gawel, J.F. Mulvey, A.A.I. Norman, T. Nishimura, Y. Tsujihata, A. Logan, O. Sauchanka, S.T. Caldwell, T.A. Prime, G.R. Bates, D. Aksentijevic, M.P. Murphy
Free Radical Biology and Medicine (2023)

Rapid and selective generation of H₂S within mitochondria protects against cardiac ischemia‑reperfusion injury

J. Miljkovic, N. Burger, J.M. Gawel, J.F. Mulvey, A.A.I. Norman, T. Nishimura, Y. Tsujihata, A. Logan, O. Sauchanka, S.T. Caldwell, J.L. Morris, T.A. Prime, S. Warrington, J. Prudent, M.P. Murphy
Redox Biology (2022)